In this article, we argue that schooling and school reform in the 21st century continues to be approached as if it were a flatworm capable of replicating itself. These reform efforts in today’s No Child Left Behind environment reify static ideas about schooling, resulting in organizational entropy. Instead, we present the process of Indigenous Invention as one that holds promise in moving our schools from entropy to renewal. Indigenous Invention grows from new conceptions of learning, cognition, and development, and our work in schools and communities during the past 16 years. We end with a discussion of the crucial values, dispositions, and conditions that have been identified for promoting Indigenous Invention. Indigenous Invention provides educators opportunities to imagine and invent new practices and schools called for in this “flat world.”